Cancer - Prostate(구연) (E-120) 근치적 전립선절제술 후 조기 요자제의 예측인자로서의 술 전 과민성 방광 : 전향적 관찰연구 경북대학교 의과대학 비뇨의학교실 장세원, 변경현, 민경찬, 정재욱, 하윤석, 최석환, 김범수, 김현태, 김태환, 유은상, 이준녕, 권태균 Background and Objectives: Postprostatectomy incontinence has been mainly attributed to the stress urinary incontinence by the deficiency of the external urethral sphincter. However, overactive bladder (OAB), occurred by detrusor overactivity, has been regarded as one of the potential factors negatively affecting the recovery of urinary continence after radical prostatectomy (RP). In this study, we evaluated the significance of preoperative OAB as a predictive factor for early acquisition of urinary continence following RP. Materials and Methods: We prospectively examined 270 patients with clinically localized prostate cancer who underwent RP in our institution from January 2018 to June 2019. We assessed International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), and uroflowmetry before surgery. Preoperative OAB was defined by total score ≥ 3 and pre-Q3 ≥ 2 on preoperative OABSS. Early acquisition of urinary continence was defined as pad-free continence recovery at 3 month follow-up after RP. Patients who have received OAB-related treatment before surgery were excluded in this study. We evaluated the patients’ demographics and outcomes according to the urinary continence at 3 months after RP. Predictive factors for early acquisition of urinary continence after RP were analyzed using univariate and multivariate logistic regression model. Results: Preoperative OAB was observed in 87 (32.2%) patients. At 3 month follow-up after RP, 130 patients (48.1%) showed pad-free continence recovery. The incidence of continence at 3 months after RP in patients with preoperative OAB (27.6%) was significantly lower than in those without preoperative OAB (57.9%). In addition, patients with early acquisition of urinary continence were younger and had lower preoperative IPSS score and lower OABSS total score compared to those without continence. In multivariable regression analysis, age and preoperative OAB were independent predictors for early acquisition of urinary continence at 3 months following RP. Conclusion: Age and preoperative OAB were independent predictors of early acquisition of urinary continence after RP. Our results suggest that physicians should consider preoperative OAB as a predictive factor for early acquisition of urinary continence after RP. keywords : Prostate cancer, Prostatectomy, Overactive urinary bladder