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The effects of adding metabolic syndrome components on the incidence benign prostatic hyperplasia: Forward to personalized prevention of BPH |
| 서울특별시립 보라매병원 |
| 고용석, 유상준, 추민수, 조민철, 정현, 손환첣 |
Introduction: We evaluated the effects of adding metabolic syndrome components on the incidence benign prostatic hyperplasia (BPH) using national health insurance database.
Methods: We initially selected 130 454 men who underwent health checkups in 2009 from the National Health Information Database of the National Health Insurance Service. After excluding 36 854 men with BPH in 2009, and 45 061 men for statin use, 48 539 men were ultimately included in the analysis. Before the analysis, study population was stratified according to age group (40s vs. 50s vs. 60s vs. 70s). The incidence of newly developed BPH during 5-year follow-up duration was estimated according to the number and types of metabolic syndrome components.
Results: Incidence of BPH in men without any metabolic components at 5-year after health check-up were as follows: 2.86% (95% CI: 2.34-3.46) in 40s, 3.86% (95% CI: 3.40-4.35) in 50s, 8.48% (95% CI: 7.3-9.70) in 60s, 10.34% 95% CI: 8.40-12.56) in 70s. In all age group, adding a single component of metabolic syndrome did not significantly increase the incidence of BPH in men with 0 or 1 baseline metabolic syndrome components. In men with 2 metabolic components, adding diabetes in 50s men with waist circumference ≥ 90cm and hypertension (2.85% vs. 6.32%, p<0.05) and adding decreased HDL-cholesterol in 50s men (3.87% vs. 6.66, p<0.05) and 60s men (5.76% vs. 10.14, p<0.05) with hypertension and TG only significantly increase the risk of BPH.
Conclusion: Based on the results of the current study, prevention of BPH by controlling the metabolic syndrome could be personalized and optimized.
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keywords : BPH, Metabolic syndrome |
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