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과민성방광에 대한 항무스카린제제 사용과 치매의 위험성의 상관관계 : 메타분석과 체계적 분석 |
| 순천향대학교 서울병원 비뇨의학과교실¹ |
| 김도경¹, 박재준¹, 이현영¹, 박준영¹, 두승환¹, 김재헌¹, 양원재¹, 송윤섭¹ |
Objective : To investigate the effect of bladder antimuscarinics on risk of dementia using meta-analysis among the randomized clinical trials (RCTs).
Meterials and Methods : A systematic review of the literature published until November 4, 2019 was performed using the PubMed/Medline, Embase and Cochrane Database. Among the 108 articles screened, 12 articles were selected for qualitative analysis and 5 articles (n=690636) included for data synthesis and current analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). Criteria for final inclusion were RCTs
Results : In this study, the risk of dementia in the exposure group compared to the control group and the prevalence of dementia in the exposure group were analyzed, respectively.
Three studies were included in the analysis for the risk of dementia in the exposure group compared to the control group (exposure group (n=34518), control group (n=284091)). Odds ratio was 1.453 (95%CI : 1.413, 1.495).
Five studies were included in the analysis for the prevalence of dementia in the exposure group (total exposure group (n=101976)). The prevalence of dementia in exposure group was 0.0243 (95%CI : 0.014, 0.034).
Conclusions : This study showed increasing risk of dementia after medication of antimuscarinics and considerable prevalence of dementia in the antimuscarics-taking group.
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keywords : bladder antimuscarinics, dementia, OAB |
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