Cancer - Kidney(구연) (E-095) 신부분절제술 후 육종양 분화도를 지닌 투명세포성 신세포암과 유두상 신세포암의 기능적 결과와 종양학적 결과 비교 분당서울대학교병원 비뇨의학과, 서울대학교 의과대학 비뇨의학교실 김환익, 노진, 김정권, 이학민, 오종진, 이상철, 변석수, 홍성규 Objective: The purpose of the study was to evaluate clinical features and prognostic factors in a large single institutional cohort of clear cell renal cell carcinoma with sarcomatoid differentiation (sRCC) and papillary renal cell carcinoma (pRCC) patients with partial nephrectomy (PN). Patients and methods: Clinicopathological parameters of all patients with sRCC diagnosed and surgically treated with PN at a single tertiary referral center between 2007 and 2016 were identified and compared with patients treated for pRCC in the same study period. The glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) formula were compared between groups. Recurrence-free survival (RFS) and overall survival (OS) were analyzed. Results: 38 patients with sRCC (, and OS, 96.9%) and 137 patients with pRCC (5-year RFS, 96.8%, and OS, 90.2%) were included in the analysis. Patients with sRCC had higher preoperative Glomerular filtration rate (GFR) (93.8 vs. 81.4; p=0.003), showed more agressive T stages (T1b-3a in 55.3% vs 16.8%; p<.0001) and higher nuclear grade (3-4 in 100.0% vs 58.9%; p<.0001), more necrosis (p<0.001) and capsular invasion (p=0.047) compared with pRCC patients. At postoperative 1st and 2nd year, there was no significant difference in MDRD GFR, respectively (p=0.051, p=0.662). Pathologic T3a stage (p=0.011), Higher nuclear grade (p=0.009) and tumor necrosis (p=0.048) are significantly associated with adverse RFS. Capsular invasion (p=0.043) and Lymphovascular invasion (p=0.010) are significantly associated with adverse OS. Conclusions: Patients with sRCC have more probability of recurrence but not worse survival and postoperative renal function compared to patients with pRCC. Nevertheless, patients with pathologic higher stage and adverse pathological features need to be thoroughly followed-up with caution of recurrence and poor survival. keywords : Partial nephrectomy; Clear cell Renal cell carcinoma with Sarcomatoid differentiation; Papillary renal cell carcinoma.