Endourology & Stone Disease(구연) (E-153)

미세칼슘결석과 결합할 수 있는 생체친화성과 항균성을 가지는 알긴산(alginate) 겔(gel) 복합체 제조
양산부산대학교병원 비뇨의학과
송원훈, 이단비, 백승룡, 이승수, 남종길, 박성우
Objectives: Even in endoscopic stone removal using a laser, it is difficult to remove completely the fine dusting sandy stones. This study aims to prepare an alginate gel composite having antimicrobial properties that can completely remove stones.
Material and Methods: Using calcium oxalate monohydrate, beta-tricalcium phosphate, and uric acid powder reagents, the binding with sodium alginate and the possibility of gel composite formation were evaluated. The stones of 17 patients who underwent surgery was crushed to form a sandy stones, and gel formation with sodium alginate was evaluated. A gel composite containing silver nitrate and an antibiotics was prepared, and an antibacterial test was performed.
Results: A mixture of 2.0X10-2M calcium oxalate monohydrate and 1.3X10-2M sodium alginate formed a precipitate over 12 hours. A mixture of 6.4X10-3M beta-tricalcium phosphate and 1.3X10-2M sodium alginate, and a mixture of 5.9X10-3M uric acid and 1.3X10-2M sodium alginate formed precipitates over 12 hours. When high concentration of 2.0X10-1M sodium alginate with calcium oxalate were mixed, a highly viscous gel composite was immediately formed. The patient's sandy stone formed of calcium oxalate prepared better gel composite when mixed with sodium alginate than uric acid sandy stones. The antibacterial test of the gel composite of sodium alginate, silver nitrate and vancomycin showed excellent antibacterial activity without cytotoxicity.
Conclusion: The alginate gel composite having antimicrobial activity that can be combined with sandy stones could be prepared.
keywords : alginate gel composite, sandy stones, antibacterial property

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