|
|
|
전립선 비대증 환자에서 약물 치료 후 전립선 크기 변화에 따른 저항지수와의 연관성: 전향적 연구 |
| 동국대학교 의과대학 비뇨의학과교실 |
| 박동진, 권세윤, 서영진, 이경섭 |
Purpose: To compare with the correlation of resistive index (RI) according to changes in the size of prostate after medical treatment in patients with benign prostate hypertrophy (BPH) prospectively.
Material & Methods: In this prospective study, 86 patients with BPH were included. All patients were treated with α adrenergic blockers and 5 α reductase inhibitors (5ARI). The variables contain prostate-specific antigen (PSA), international prostate symptom score (IPSS) and quality of life score (QoL), maximal urinary flow rate (Qmax), residual urine volume, total prostate volume, transition zone volume (TZV), and RI of the urethral artery, left and right capsular artery was evaluated at baseline and after 3- and 6-months treatment. 23 patients who have a TPV less than 30cc or incomplete RI data were excluded. A total of 63 patients were analyzed.
Results: The mean age of patients was 70.0±7.5 years old. The IPSS before treatment was 19.8±6.8, and after 3- and 6-months of treatment, it decreased to 16.6±7.4 and 16.0±8.0, respectively (p < 0.001). The QoL before treatment was 4.0±1.1, and after 3- and 6-months of treatment, it decreased to 3.1±1.3 and 3.1±1.4, respectively (p < 0.001). The TPV before treatment was 45.0±15.4, and after 3- and 6-months of treatment, it decreased to 39.8±16.6 and 37.4±14.2, respectively (p < 0.001). The Qmax before treatment was 9.5±3.7, and after 3- and 6-months of treatment, it increased to 14.2±15.4 and 15.0±13.3, respectively (p = 0.004). The RI of the urethral artery before treatment was 0.69±0.09, and after 3- and 6-months of treatment, it decreased to 0.67±0.08 and 0.65±0.10, respectively (p = 0.011). The RI of the left capsular artery before treatment was 0.69±0.08, and after 3- and 6-months of treatment, it decreased to 0.68±0.08 and 0.66±0.11, respectively (p = 0.015). The RI of the right capsular artery before treatment was 0.70±0.09, and after 3- and 6-months of treatment, it decreased to 0.66±0.08 and 0.65±0.09, respectively (p < 0.001).
Conclusion: In patients with BPH, the α adrenergic blockers and 5ARIs medications for 3- and 6-months showed statistically significant decreases in the RI of the urethra and both capsular arteries. Further studies on the relationship between TPV reduction and RI are needed.
|
|
keywords : benign prostrate hyperplasia, resistive index, transrectal ultrasonography |
|
