Cancer - Prostate(구연) (E-116) 전립선암 환자에서 남성 호르몬 차단 요법이 치매 발생에 미치는 효과:한국 보험공단자료를 이용한 후향적 Propensity 점수 매칭 연구 1 비뇨의학과 2 암정책과 3 건강보험연구과 4 신경과 김성한1, 김영애2, 이강현1, 양민수3, 박종환3, 김수현4, 정재영1 Back ground Androgen deprivation therapy (ADT) is designed to block androgen, also known as testosterone to prevent the progression of prostate cancer (PC). The andropause brings in multiple adverse effects, such as obesity, anemia, osteoporosis, gynecomastia, muscular atrophy, and mood changes, depending on the duration of administration, type of combinational agents used. Recent reports have suggested a dementia-like cognitive dysfunction as a side effect of ADT Objective This study aimed to evaluate the duration effect of androgen deprivation therapy (ADT) on the prevalence of dementia in patients with prostate cancer (PC) using population-based data from the Korean National Insurance Database. Method Between 2003 and 2013, 31571 patients with PC diagnosed under the C61 and aged >50-year-old were selected after the exclusion of those with cerebrovascular disease and dementia before or within 3-month-ADT and with surgical castration. A total of 9798 patients were grouped into ADT and non-ADT group after 1:1 Propensity-score (PS) matching for differential baseline characteristics. The ADT and non-ADT groups were then compared statistically to define the significant relationship between ADT duration and prevalence of dementia which were Parkinson, Alzheimer and vascular and other types of dementia with a statistical significance of p-values less than 0.05. Results After PS matching, two groups were insignificantly different for age, body mass index, SEER stage, year of dementia diagnosis, smoking state, underlying disease, and current anticoagulant history (p>0.05). The multivariate analysis showed that age, obesity, ex-smoker history, Charlson comorbidity index, and ADT duration were significant risk factors for dementia (p<0.05). Especially the ADT duration of 6-12-month (Hazard ratio [HR], 1.445) and of 24-month longer (HR, 0.621) duration had a significantly different prognostic direction for dementia prevalence. Further multivariate analyses for dementia subtype showed that ADT duration affected significantly on Alzheimer's and vascular dementia types (p<0.05).  Conclusion The study showed that the prevalence of dementia was affected differently by the ADT according to its duration.  keywords : Keywords: prostate cancer, prevalence, dementia, hormonal therapy, matching