Incontinence & Female Urology & Neurourology(구연) (E-179) The efficacy of vaginal moisturizers composed β-glucans in treatment of vulvo-vaginal atrophy with post-menopausal women. 고려대학교 구로병원 비뇨의학과. 한다은, 박홍석, 오미미, 김종욱, 안순태, 이동현, 문두건* Introduction and objective: Vaginal dryness is common symptom of vulvo-vaginal atrophy (VVA) that is prevalent with post-menopausal women. While estrogen replacement is effective, it is not suitable for all women. We focused natural β-glucans which possess anti-infection, immune-modulating and moisturizing properties. This study was aimed to investigate the efficacy and safety of vaginal moisturizers with β-glucans on VVA related vaginal dryness. Methods: The prospective single-arm study was conducted between Jan 2019 to July 2019. Sexually active women aged 45 years or older with moderate to- severe vaginal dryness were enrolled. All patients were given vaginal moisturizers composed of 0.6 % β-glucan for 7 days. Efficacy was assessed by the vaginal pH, vaginal swab culture, and a self-assessed 5-point scale of VVA related symptoms questionnaire consist of vaginal itching, irritative burning sense, pain, dryness, discharge, four odor and dyspareunia. This study was approved by the Institutional Review Board of the Korea University Hospital. Result: 35 patients were treated with vaginal moisturizers composed of 0.6% β-glucan. Mean aged was 58.1±5.9(range: 51-77). After 7 days of treatment, symptoms scores regarding vaginal dryness(from 4.2±0.4 to 0.9±0.7, p<0.001), itching(from 1.3±0.3 to 0.3±0.6, p<0.001), burning sense(from 1.4±1.8 to 0.6±0.8, p=0.009), pain(from 1.0±1.6 to 0.4±0.8, p=0.012), four odor(from 0.7±1.1 to 0.2±0.5, p=0.004), dyspareunira(from 2.2±1.7 to 0.4±0.8, p<0.001) were improved while no improvement was observed for vaginal discharge (p=0.377). Significant decrease in vaginal pH was detected (from 7.1±0.7 to 4.9±0.9, p<0.001). Overall, 68.6% (24/35) patients increased lactobacillus genus assessed by quantitative analysis. All patients were tolerated and no adverse events was reported. Conclusion: The vaginal moisturizers composed β-glucans was effective in VVA associated symptoms and showed prebiotic activity in 2/3 patients after treatment. keywords : post-menopausal women, vulvo-vaginal atrophy, β-glucans