Cancer - Bladder, Pelvis, Ureter & Others(구연) (E-055) Ta 고등급 병기의 방광암에서 경요도방광종양절제술의 재시행을 통해 얻게 되는 임상적 유용성에 대한 연구 서울대학교 의과대학 비뇨의학교실 유상현, 윤현식, 정규환, 박대형, 고용석, 김승이, 서준교, 육형동, 정창욱, 김현회, 곽철, 구자현 Objective Current guidelines recommend repeat transurethral bladder tumor resection (re-TURB) for bladder cancer identified as Ta high grade (TaHG). We evaluated the therapeutic benefits of re-TURB in TaHG bladder cancer through specific statistical values. Material and Method We analyzed the patients in the Seoul National University Prospectively Enrolled Registry for Urothelial Cancer – Transurethral Bladder tumor Resection (SUPER-UC-TURB). The selected patients had TURB surgery at Seoul National University Hospital from March 2016 to December 2019, and the postoperative pathology resulted in TaHG. Additionally, we reviewed the postoperative pathology of patients who had re-TURB surgery. Then we analyzed the recurrence free survival (RFS) in each group by Kaplan-Meier analysis and Cox regression analysis. Result The total number of patients was 187, of which 115 were re-TURB treated and 72 were not. The remaining tumor was found in 36.5% (42 cases) of the re-TURB cases. The distribution of cancer stage was Tis 13, Ta 24, T1 5. When we performed Kaplan-Meier analysis, the re-TURB treated group showed significantly higher 2-year recurrence free survival (RFS) than the control group (81.3% vs. 75.5%, p=0.005). In Cox regression analysis, the control group significantly increased the risk of recurrence (Hazard ratio 3.22, CI 1.52-6.83, p=0.002). Conclusion There was a benefit of additional removal of residual tumor by repeating TURB in TaHG bladder cancer. Additionally, when they were not treated with re-TURB, the risk of bladder cancer recurrence was significantly increased. This findings suggest that re-TURB should be performed in TaHG bladder cancer. keywords : bladder cancer, Ta high grade, repeat transurethral resection of bladder