Incontinence & Female Urology & Neurourology(구연) (E-174) 비신경인성 하부요로증상을 보이는 지역사회 거주 노인 환자군에서 배뇨근과활동성 및 수축력저하 질병의 유병률과 요역동학적 특성: 단일 또는 독립된 두 방광질환에서 기인한 것인가? 서울대학교 의과대학 비뇨의학교실, 분당서울대학교병원, ¹서울특별시립 보라매병원, ²서울대학교병원 정성진, 이민승, 송상헌, 김학주, 추민수¹, 조성용², 오승준², SEOUL Study Group Purpose: The symptoms of detrusor overactivity with impaired contractility (DOIC) are not a little encountered in clinical practice, however, its pathogenesis and clinical characteristics have not yet been clearly identified. we aimed to identify the prevalence of DOIC in the community-dwelling elderly with non-neurogenic lower urinary tract symptoms and compare urodynamic characteristics of DOIC with those of detrusor overactivity (DO) and detrusor underactivity (DU) in order to explore whether it is from a single or two independent bladder dysfunctions. Materials and Methods: Based on a 10-year urodynamic database of the SEOUL Study Group, elderly patients aged 65 or older who met inclusion criteria were selected. Bladder sensation, capacity, and compliance were designated as evaluation elements for storage function, and free maximal flow rate (Qmax) and post void residual volume, detrusor pressure at maximal flow (PdetQmax), and bladder voiding efficiency for voiding function. Results: Of 2,571 men and 688 women, the prevalence rate of DOIC was 18.8% and 5.5% in male and female population, and increased significantly with age (Fig. 1). In men, patients with DOIC showed no differences in storage parameters and significantly lower free Qmax and PdetQmax among voiding parameters, compared to those with DO only. Compared to men with DU only, those with DOIC had worse parameters in the majority of storage and voiding functions. In women, most of the storage and voiding functions were worse in patients with DOIC than in those with DO only. On the other hand, women with DU showed lower PdetQmax and worse voiding functions than those with DOIC, although some parameters did not reach statistical significance. Conclusions: Urodynamically, the association of DOIC with DO and DU may be different between both sex. In men, it seems that DOIC is developed from a coincidental combination of two independent DO and DU. In contrast, DOIC is likely to be an intermediate step during the process of progression from DO to DU in women. keywords : Detrusor overactivity, Detrusor overactivity with impaired contractility, Detrusor underactivity