Cancer - Prostate(구연) (E-113) 전립선암 진단에 있어서의 Prostate Health Index (PHI)의 유용성 인제대학교 의과대학 비뇨기과학교실 김재윤, 조대연, 성락희, 정재용, 유지형 Purpose We aimed to evaluate the usefulness of the Beckman Coulter prostate health index (PHI) comparing with tPSA and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in Korean population. Meterial and Methods A total of 140 men who underwent their first prostate biopsy were included in this prospective, observational study. Diagnostic accuracy of tPSA, free PSA, %fPSA, p2PSA, %p2PSA, and the PHI was assessed by receiver operating characteristic curve analyses and logistic regression analyses. Results Overall, PCa was detected in 60 (42.9%) subjects and 51 (85%) was significant cancer, gleason’s score ≥7. PHI was the most accurate predictors of PCa and significantly outperformed tPSA (p= 0.036); area under the curve for tPSA and PHI was 0.630 and 0.722, respectively. Additionally, PHI was also the stronger predictor of PCa with Gleason score ≥ 7 than total PSA with significant difference (p=0.022). Conclusion This study shows PHI is superior to total PSA in predicting the presence and aggressiveness of PCa in Korean men. The PHI improve detection of PCa and provide prognostic information. keywords : prostate cancer, prostate health index, diagnostic accuracy